Abstract: The plant power system is a core component of the production process of thermal power plants, and is a key foundation for ensuring the safety of equipment during the start stop, normal operation, and accident conditions of power generation units. Its operational stability directly determines the production safety of thermal power plants and the power balance of the power system. This article elaborates on the core importance of safe operation of the power system in thermal power plants. It systematically analyzes the four core risks and accident causes that affect the safe operation of the system: equipment, protection, operation and maintenance, and working environment. Targeted safety operation guarantees and accident prevention measures are proposed for the entire process, providing reference for improving the safety control level of the power system in thermal power plants and preventing unplanned shutdown accidents.